NAOS collaborates with experts to better understand the skin and its needs
NAOS AGING SCIENCE, a major scientific discovery on the primary causes of skin aging.
Our skin is programmed to maintain its own health and functionality. It has natural mechanisms that need to be supported and strengthened to fight against aging.
By identifying the causes of skin imbalances, beyond the symptoms, NAOS AGING SCIENCE works on the causes of the acceleration of aging: oxidative stress, inflammaging, photoaging, microbiome and proteome science.
Inspired by the work of Professor Miroslav Radman on the role of the proteome as a guarantor of cell longevity, NAOS research teams discover the way to protect the proteome from damage to maintain the skin's youthfulness.
Protecting the proteome, the new paradigm of longevity
Carbonylation, the leading cause of irreparable alteration of the skin proteome
Antioxidant chaperone molecules, acting on the causes of skin aging
01. Protecting the proteome, the new paradigm of longevity
Miroslav Radman, an internationally renowned geneticist and molecular biologist and founder of the Mediterranean Institute for Life Sciences (MedILS) studies the most robust organisms.
Such robust organisms, whose biology has been optimized by billions of years of evolution, manage to survive and flourish in extreme conditions of temperature, pH, salinity or radiation.
Professor Radman’s discovery is astonishing: radiation resistance and longevity can be accounted for by extremely efficient protection of the proteome, not the genome, against oxidative damage.
02. Carbonylation, the leading cause of irreparable alteration of the skin proteome
With time and external aggression, the skin proteome is subject to various alterations. The most redoubtable is carbonylation, an irreversible damage linked to oxidation. Carbonylated proteins can no longer perform their biological functions.
They must then be recycled or eliminated. With age, they are more difficult to eliminate and accumulate in the form of toxic aggregates that hinder cell physiology and accelerate aging. This irreversible alteration of proteins, whether structural such as collagen or elastin, or functional such as DNA repair enzymes, results in the appearance of wrinkles, a dull and less even complexion, a loss of pigmentation and firmness or density.
03. Antioxidant chaperone molecules, acting on the causes of skin aging
Inspired by Prof. Radman’s work, NAOS researchers in turn discovered in 2010, in snowflakes, the Arthrobacter agilis bacterium, or snow bacteria:
With an astonishing capacity for survival, enabling it to resist UV radiation and oxidative stress.
It is the most protective candidate for skin cells due to its high content of bacterioruberins, biological pigments with biomimetic properties of the skin’s natural defense systems and particularly effective proteome protectors.
Through their dual mechanism of action, chaperone and antioxidant, these molecules, which are the result of billions of years of evolution, prevent irreversible damage to the skin proteome and enable better cellular and tissue functionality to be restored in the long term.
“This new approach constitutes a first-rate protection against skin aging: by intervening upstream on the mechanisms involved in cellular longevity, the beneficial downstream effects are visible on all the signs of aging.”
Isabelle Benoit, a member of the NAOS scientific committee
NAOS Laboratories and MedILS, a partnership guided by a common vision
NAOS has developed particularly close ties with Professor Miroslav Radman long before NAOS AGING SCIENCE.
The French-Croatian professor is a cellular biologist who studied at Harvard and is a member of the Académie des Sciences. He is the founder of the Mediterranean Institute for Life Sciences (MedILS).
Since the 2000’s, Jean-Noël Thorel, pharmacist-biologist, and founder of NAOS, has been associated with the research of Prof. Radman, whose work on longevity and cellular regeneration has revolutionized the understanding of aging and age-related pathologies such as diabetes, Parkinson’s disease, Alzheimer’s disease and Charcot’s disease.
Jean-Noël Thorel and Professor Miroslav Radman share the same passion for human biology and evolutionary concepts with the goal of reducing human suffering.
Today, this relationship has been materalized throught a partnership between NAOS Institute of Life Science and the MedILS on the topic of cutaneous ageing. (www.medils.org)
Collaborating with renowned academics, NAOS has created a unique network of expertise.
NAOS ambition is to bring together the best researchers in each of their specialties.
By sharing the importance of its mission and of the ecobiological approach, NAOS brings to life a global network of academics with whom innovative solutions can freely be explored.
The creation of an active network of researchers allows NAOS to quickly adapt its research programs but also benefit from the most up-to-date equipment.
NAOS scientific committee is integrated into the company’s governance system.
The creation of NAOS Institute of Life Science
In May 2016, Jean-Noël Thorel set up NAOS ILS (Institute of Life Science) to anchor the company’s capacity for innovation by reinforcing links with associated high-level researchers.
Upstream from NAOS, NAOS ILS invests in large-scale research projects that target ecobiology with the goal of applying the research to the Human Care domain (Heart, Body and Mind).
Research and Development (R&D)
R&D Department
Since
1988
An independent French laboratory based in Aix-en-Provence and 2 investigation and clinical research centres based in Lyon and Buenos Aires.
NAOS People/scientists
committed to our patients/consumers
User listening studies, trend decoding, and market analyzis to create innovative concepts.
Permanent scientific watch in skin biology and development of innovative models in our own biological research laboratory.
Formulatory and packaging expertise to ensure efficacy, tolerance, sensoriality and practicality for each product.
Rigorous monitoring and compliance with international regulations. Toxicological expertise & permanent watch about ingredients.
Systematic assessment of product efficacy and tolerance on healthy volunteers and clinical trials with international CROs in our own clinical research centers (based in France & Argentina).
Research programs driven by ecobiology
international publications.
national & international posters.
collaborations with national & international KOL.
millions of euros of investiments planned in the next 3 years and 30 ongoing research programs.
One year of innovation at NAOS
in-vitro tests on 1.2 billion skin cells to assess and compare active ingredients.
user talk analysis to provide insight-based innovation.
ecobiological formulas to create new products or improve the quality and efficacy of existing ones.
safety tests to ensure the innocuity & tolerance of our products.
efficacy tests on volunteers & clinical studies under medical supervision to assess the efficacy of our products in real condition of use.
patents.
At the heart of a complete scientific ecosystem
to challenge our concepts, select the best biological targets and design innovative technologies.
to identify the root causes of skin disorders and perform clinical studies on patients in real condition.
to develop innovative and exclusive ingredients or evaluation models.
Ingredient expertise
ecobiological selection criteria (biomimetic, pure molecules, polyfunctional ingredients, interacting with biological skin mechanism).
biomimetic active ingredients, identical or similar to natural skin constituents, to ensure the best skin affinity & optimal biological activity.
ingredients strictly selected among 30.000 available in the cosmetic industry (=2%).